Small Cell Neuroendocrine Carcinoma of the Palatine Tonsil After Concurrent Chemoradiotherapy for Laryngeal Cancer: A Rare Case Report
Bo-Nien Chen1, Chih-Yung Yang and Shiuan-Li Wey
Journal Title:Acta Scientific Otolaryngology
Objectives: Small cell neuroendocrine carcinoma (SCNEC) of the palatine tonsil is extremely rare, highly invasive, and associated
with poor prognosis. Herein, we present an extremely rare case of SCNEC of the palatine tonsil after concurrent chemoradiotherapy
(CCRT) for laryngeal cancer. We also provide a brief review of its clinicopathological characteristics and treatment modalities.
Methods: A 66-year-old Taiwanese woman visited our hospital with a 2-week history of left-sided sore throat. She had a history of
laryngeal cancer treated with CCRT 5 years ago. Asymmetric enlargement of the left palatine tonsil with extensive ulceration was
noted. Biopsy of the left palatine tonsil was performed, and SCNEC was diagnosed. The patient subsequently underwent surgical
intervention (wide excision of the left palatine tonsil and left supraomohyoid neck dissection) and adjuvant chemotherapy.
Results: The patient tolerated the treatment well and symptoms resolved. Tumor recurrence was not observed in follow-up mag-
netic resonance imaging after therapy at the 12-month follow-up time point, and the patient has resumed a normal life.
Conclusion: This report highlights the importance of considering the effect of CCRT on SCNEC occurrence and expands the spectrum
of reported radiation-induced neoplasms in the head and neck region. It is critical for clinicians to be aware of this extremely rare
and highly invasive malignancy.
Keywords: Small Cell Neuroendocrine Carcinoma; Concurrent Chemoradiotherapy; Postradiation Neoplasia; Tonsillar Malignancy