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Paper Details

Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol

Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol

Sarbjeet Singh1, Mandeep Kaur2*

Journal Title: Journal of Clinical Medical Research
Abstract


Paracetamol is that the one amongst the foremost broadly speaking NSAIDS used as antipyretic and analgesic drug within the world. However, still its Mechanism of Action (MOA) is not fully recognize.  The potential Mechanism of Action (MOA) of paracetamol as its antipyretic and analgesic impact was thought multiple pathway. Some action relies on the inhibition of the Cyclooxygenases (COX enzyme) and a lot of recently study show that it additionally acts on serotonergic pathways (5HT pathway). A brand new metabolic pathway of paracetamol (as a prodrug) is come back to grasp, involving the generation of a lively matter, AM404 (N-4Hydroxyphenyl-5Z, 8Z, 11Z, 14Z-eicosatetraenamide), by the (FAAH) carboxylic acid organic compound hydrolase protein within the brain, was recently known. This review describes the theoretical knowledge that show the affiliation of this metabolic pathway within the analgesic & antipyretic action of acetaminophen (PCM) and its relationship with the enzyme protein (COX) and (5-HT) serotonergic systems. It additionally shows that the new systems (cannabinoid and vanilloid systems) and targets as well as the atomic number 20 channel receptor (Cav3.2), play an important role within the flightless bird of paracetamol.