Potential Risk Factors of Glioblastoma Multiforme in Greek Adults: A Case- Control Study
Nikolaos Andreas Chrysanthakopoulos1,2*, Panagiotis Andreas Chrysanthakopoulos3
Journal Title: Journal of Clinical Medical Research
Aim: The aim of the current report was to assess the association between potential risk factors in the pathogenesis of Glioblastoma Multiforme (GBM) in a Greek adult sample.
Materials and Methods: The study sample consisted of 68 individuals who suffered from GBM and 280 healthy no GBM individuals. Initial diagnosis of GBM based on Magnetic Resonance Imaging (MRI) findings diagnosis, however definitive confirmed by the histopathological examination of the intraoperatively removed tumor or its parts, using traditional histological, cytologic and histochemical methods .The associations between known potential risk factors of GBM and the GBM risk was assessed using univariate and multivariate logistic regression analysis models.
Results: The application of logistic regression model showed that higher Socio-Economic Status (SES) (p=0.032, OR=3.79, 95% CI=1.36-8.61), previous infection with Cytomegalovirus (CMV) (p=0.048, OR=3.11, 95% CI=1.12-6.89), and previous Traumatic Brain Injury (TBI) (p=0.028, OR=5.58, 95% CI=2.14-11.40), were statistically significantly associated with GBM risk.
Conclusion: Higher SES, previous CMV infection and previous TBI were significantly associated with the risk of developing GBM.