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Paper Details

Scaffolds Combined with Stem Cells have Synergistic Effect in Regenerative Dentistry

Scaffolds Combined with Stem Cells have Synergistic Effect in Regenerative Dentistry

Michel Goldberg1*

Journal Title: Journal of Clinical Medical Research
Abstract


Tissue engineering generates alternatives for tissues regeneration and/or reconstructive surgery. Materials and fabrication technologies are important in designing temporary extracellular matrices (scaffolds), implicated in three-dimensional tissue formation. In this review, we reference the relationship between tissue engineering and materials science. Materials for porous solid-state scaffolds include linear aliphatic polyesters Poly Glycolic Acid (PGA) and their co-polymers Poly Lactic-Co-Glycolic Acid (PLGA), poly (Ɛ-caprolactone) (PCL) and Poly Hydroxyl Butyrate (PHB)]. Biodegradable polymers include Poly Propylene Fumarate (PPF) and phosphoresters. Natural macromolecules such as proteins and polysaccharides including collagen, either denatured as gelatin, or combined with glycosaminoglycan(s), silk, alginate, chitosan, and hyaluronate. Inorganic materials are categorized as porous bioactive glasses or calcium phosphate, β-tricalcium phosphate, hydroxyapatite and their derivatives. Research’s on implantable materials for tissue regeneration shed lights on biodegradable polymers and specifically, on synthetic proteins promoting regeneration of the dental pulp despite infectious degradation and necrosis of the pulp tissue.