Microfracture and Hydrogel Scaffolds for the Treatment of Osteochondral Injuries of the Knee: Clinical Results at 4 Years Follow-Up
Pipino Gennaro1,2, Borghi Raffaele2, Vaccarisi Davide C2, Mardones Rodrigo3, Giardini Piero2, Alessio Giai Via4, Indelli Pier Francesco5*
Journal Title: Journal of Clinical Medical Research
The aim of this study is to evaluate the outcomes of microfracture technique and novel hydrogel scaffold for the treatment of osteochondral injuries of the knee.
Forty-one patients affected by grade III and IV osteochondral lesions were treated between 2014 and 2015 with microfractures followed by the injection of a hydrogel scaffold into the defect. All patients have been evaluated pre-operatively, at 6 months, 1, 2, 3 and 4 years postoperatively (WOMAC and VAS scores).
The initial total WOMAC score was reduced by 83% at 6 months, 90% at 12 months and 87% at 4 years. The initial VAS score was reduced by 78% at 6 months, 82% at 12 months and 83% at 4 years. All the scores, including total and sub-scores, statistically improved in all follow-ups compared to preoperative data.
Our results showed an improvement of clinical outcomes and pain after the microfractures technique has been combined with the use of a hydrogel scaffold, which have been maintained at 4 years follow-up.