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Paper Details

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Asmaa Fathi Hamouda1,2*, Taymour-Lank Mohammed Farawilla3, Ibraheem Mohammed Attafi4, Ibrahim Abdu Khardali4, Mohammad Ahmad Attafi4, Magbool Essa Oraiby4, Farid Mohammad Abualsail4

Journal Title: Journal of Clinical Medical Research
Abstract


Background: Since 2019, several critical effects of the coronavirus pandemic have surfaced, including its psychological problems such as depression. The World Health Organization has approved a group of drugs and vaccines. However, the world still faces novel coronavirus mutations, requiring more ideas to investigate a drug, vaccine and phytochemical potential chemoprevention proposal. Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV)-2 co-operates directly with the Angiotensin-Converting Enzyme 2 (ACE2) to penetrate the target cells. Aims: We aim to introduce the possibility of studying seed oil extract as an anti-depression, anti-stress, anti-epinephrine receptor (PDB: 2rh1) and as potentially binding anti-angiotensin-converting enzyme 2 (ACE2) agent. Methods and Methodology: We analyze the constituents of the six studied seeds’ oil with Gas Chromatography-Mass Spectrometry (GC-MS) by performing an AutoDock analysis of the components’ potential ligands to both the 2rh1 and ACE2. Results: We observe convenient binding conformations between the investigated receptors and the 44 phytoconstituents. The AutoDock outcomes of the seeds’ phytochemical GC-MS separated components reveal highly binding energy, with ACE2 higher than 2rh1. Conclusion: The studied seed oil contains binding energy with currently studied receptors and molecular weight, which enables it to be studied in the future as a nanoparticle against viruses, vaccines and psychiatric drugs.