Chikungunya: A Neglected Tropical Disease
Rajeshwar Reddy Kasarla1*
Journal Title: Journal of Clinical Immunology AND Microbiology
Chikungunya, a mosquito-transmitted viral disease endemic to tropical regions is recurring in epidemic waves over the last 15 years, with outbreaks becoming increasingly severe, infecting over one million people annually and causing debilitating joint pain. The virus caused outbreaks throughout the world with an ability to spread to non-endemic areas. The Chikungunya Virus (CHIKV) was first described during an outbreak in 1952 on the Makonde plateau, in the Newala district, along the border, between Mozambique and Tanganyika, the mainland part of modern-day Tanzania in East Africa. It was subsequently introduced into Asia and caused several periodical outbreaks in various African and South-East Asian countries (India and Thailand) since the 1960s. Though chikungunya virus was ï¬rst isolated in 1952, its biology, transmission, and mechanism of pathogenesis has been poorly understood, and deserves more attention .