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Paper Details

The Spheroid Smarting- Glomus Tumour

The Spheroid Smarting- Glomus Tumour

Anubha Bajaj1*

Journal Title: Journal of Clinical Immunology AND Microbiology
Abstract


Glomus tumour is benign, perivascular hamartoma arising from glomus apparatus or a mesenchymal neoplasm essentially comprised of modified smooth muscle cells, also termed as glomangioma, glomangiomyoma or glomangiomatosis. Glomus tumour can arise from bi- allelic inactivation of Neurofibromatosis type 1(NF1) and emerges in concurrence with NF1 gene. Also, decimation of neurofibromin within glomus cells activates the RAS-MAPK pathway. A gradually progressive, faintly tinged, bluish-red, subungual papule demonstrating a classic triad of symptoms as localized sensitivity, pain upon exposure to cold and intense pain with minor trauma is exhibited. Morphologically, a combination of glomus cells, smooth muscle cells and cogent vascular elements is discerned. Spheroid, punched out nuclei surrounded by minimal cytoplasm, an amphophilic to eosinophilic stroma and circumscribing branching, capillary sized vasculature is delineated.