How Does Dexamethasone Work Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)?
Yusra Binte Sikandar1, Syed Abdullah Ibn Asaduzzaman1, Abrar Hamim Fayz1, Rashed Noor1*
Journal Title: Journal of Clinical Immunology AND Microbiology
The continuing COVID-19 pandemic instigated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led the scientists discover an array of candidate drugs and set up possible vaccine platforms under trial. However, till date no vaccines have been established to abate COVID-19 pandemic while a few drugs as the anti-virals or the immunomodulators have been proposed on the basis of patient trial success. One of them is remdesivir which is actually a broad spectrum anti-viral drug. Recently, the corticosteroid dexamethasone has evolved with a stunning property to cure the COVID-19 patients who have developed the Acute Respiratory Syndrome (ARDS), requiring ventilation. Several recent case studies have shown the efficacy of dexamethasone to treat the severe patients who were at the risk of death. Present review focused on the mechanism of action of dexamethasone with its specific immunological functions in course of curing the SARS-CoV-2 infection within a patient. A model regarding the mechanisms of dexamethasone action has been proposed as well.