Psoriatic Manifestation on a Healed Herpes Zoster Lesion: A Case of Koebner Phenomenon Resistant to TNF-α Inhibitors
Capalbo Alessandro1, Gagliostro Nazareno1, Balampanos Charalampos Georgios1, Bushati Vilma2, Persechino Flavia3, Giordano Domenico4, Persechino Severino4*
Journal Title: Journal of Clinical Immunology AND Microbiology
Herpes Zoster (HZ) and psoriasis are common cutaneous diseases and in some patients psoriatic manifestations may appear over healed HZ lesions. This manifestation has been defined as Koebner Phenomenon (KP) or Wolf Isotopic Phenomenon (IP).
We report a 35-year-old man with chronic moderate plaque psoriasis who developed KP at the areas of healed HZ. We noticed a lack of response to TNF alfa inhibitor treatment in the lesions previously affected by HZ. Therefore, we assume that other inflammatory mediators, in particular Substance P, can be related to the psoriatic manifestations over healed HZ lesions.