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Paper Details

Randomized Double Blind Study for Detecting Association of Globus Pharyngeus with Dietary and Daily Habits of North Indian Population and Formulating a Uniform Treatment Plan

Randomized Double Blind Study for Detecting Association of Globus Pharyngeus with Dietary and Daily Habits of North Indian Population and Formulating a Uniform Treatment Plan

Abdul Rehman Khan, Mohammad Aftab, Nizamuddin Sheikh and Nitin khari

Journal Title:Acta Scientific Otolaryngology
Abstract


Aims: Globus pharyngeus is a painless sensation in throat, described as a foreign body sensation, a tightening or choking feeling. Often associated with persistent clearing of the throat, cough, and change in voice. It makes up 4% of ENT referrals and is reported to have been experienced by up to 46% of the population. This study was done to redefine etiological factors and formulate a plan of treatment. Methods: All the consecutive patients who were having specific symptoms of foreign body sensation, vague pain and discomfort in upper digestive tract or throat were included in this study, during the 3.3 years period from 2018 January. After applying inclusion and exclusion criterias and considering consent for endoscopy 587 patients were included in the study. A uniform questionnaire was devised and all the patients were asked the same questions from the questionnaire and a proforma was filled. Patients were divided in 3 groups in 1:1:1 pattern and Group A was given placebos, Group B was give Treatment regimen as per study and Group C was given Treatment regimen plus psychotherapy, voice/speech therapy and physiotherapy. All the groups were randomized and double blinded. Statistical analysis was performed and fisher exact test and chi square tests were used to detect significance and scope of null hypothesis. Result: Most common etiological factors involved were repeated dry swallowing of saliva, going to bed late at night and intake of some specific foods which may point to some allergic cause, though it varies from place to place. In 10% of cases some psychological factor was also responsible. Treatment plan C was having most significant response, Fisher exact test and chi square tests were done for statistical analysis. The p-value is < 0.00001. The result was significant at p < .01. Conclusion: Treatment plan B and Treatment Plan C significantly improved symptoms of globus pharyngeus as compared to Plan A (placebo) group. Keywords: Globus Pharyngeus; Dietary; Daily Habits