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Paper Details

Diagnostic Implication of Bone Marrow Mesenchymal Stem Cells (BMSC) Exosomal MicroRNA-632 on Chronic Atrophic Gastritis

Diagnostic Implication of Bone Marrow Mesenchymal Stem Cells (BMSC) Exosomal MicroRNA-632 on Chronic Atrophic Gastritis

Zaibiao Wang1, Manman Yin2, Jiayun Shao3, Jie Peng1, Longhai Li2 and Liye MA4*

Journal Title:Acta Scientific Cancer Biology
Abstract


Evidence has indicated the significance of microRNAs (miRNAs) derived from Bone marrow mesenchymal stem cells (BMSC)exo- somes (BMSC-exo). We aimed to investigate the potential of miR-632 as a therapeutic target for diagnosis and treatment for chronic atrophic gastritis. We collected 96 serum samples from patients with chronic atrophic gastritis and the expression level of miR-632 was investigated in these samples by RT-qPCR. The relationship between the miRNA level and prognosis and patients’ characteristics was evaluated. The expression of miR-632 was significantly not associated with the sex, age, pathogenic site, and the size of serum BMSC-exo (p > 0.05), but miR-632 expression was related to the development of chronic atrophic gastritis and neoplastic progres- sion: gastric cancer of intestinal type group> chronic atrophic gastritis complicated with intraepithelial neoplasia group> chronic atrophic gastritis complicated with intestinal metaplasia group> chronic non-atrophic gastritis group (p < 0.05). Downregulated expression of miR-632 predicted greater survival (124.23 ± 12.43 months) compared to the higher miR-632 expression with survival time of 68.34 ± 10.90 months (p < 0.05). Expression level of miR-632 relates to the inflammation-mediated carcinogenesis and prog- nosis of chronic atrophic gastritis, which still further requires systematic investigation. Keywords: BMSC; Chronic Atrophic Gastritis; MicroRNA-632; Inflammation-mediated Carcinogenesis; Exosome