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Paper Details

Anesthetic Management of a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Symptoms (MELAS): A Case Report

Anesthetic Management of a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Symptoms (MELAS): A Case Report

Refaat Shehab1* and MO Ababneh2

Journal Title:Acta Scientific Cancer Biology
Abstract


Mitochondrial encephalopathy, lactic acidosis, stroke-like symptoms (MELAS) syndrome is a specific mitochondrial myopathy that results in defects in respiratory enzyme complexes I and IV. This ultimately causes defects in aerobic metabolism, especially in high-energy-requiring organs, leading to an obvious concern with anesthetic management. Mitochondrial disease (MD) is recognized as an important cause of a wide range of physiologic changes that affect the periopera- tive period [1], strongly affected by anesthetics. We managed a 36-year male patient with MELAS, underwent a ureteroscopy, lithotripsy and indwelling double J stent exchange. The patient was successfully managed with a spinal/epidural anaesthesia. Keywords: MELAS; Anesthetic Management; Myopathy; Genetics