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Paper Details

Comparison of Distribution of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma - A Retrospective Study

Comparison of Distribution of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma - A Retrospective Study

Himani-Tiwari Chaturvedi and Vandana Shah

Journal Title:Acta Scientific Otolaryngology
Abstract


Oral leukoplakia and oral squamous cell carcinoma (OSCC) are the commonly occurring oral diseases, with characteristic clinical and histological features. These diseases at some stages are associated with chronic inflammation in adjacent connective tissue. Mast cells are granule-containing secretory cells which are local residents of the connective, scattered along the capillaries of oral mucosa. They are proinflammatory and expressed the serine proteases, tryptase and chymase along with cytokines and may play a significant role in the pathogenesis of oral diseases. The aim of the study was to histologically evaluate and compare the presence of mast cells in Normal mucosa, Leukoplakia and Well differentiated oral squamous cell carcinoma. Thirty cases each of normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma (OSCC) were studied for mast cell number using 1% Toluidine blue. There was a lin- ear increase in mast cell numbers were seen in leukoplakia and OSCC as compared to normal mucosa. Mast cell hyperplasia in oral leukoplakia and OSCC suggests their probable role in the pathogenesis of these diseases.