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Paper Details

IDENTIFICACIN DE RIESGO DE TOXICIDAD Y OTROS PROBLEMAS RELACIONADOS CON MEDICAMENTOS EN PACIENTES AFILIADOS AL SISTEMA GENERAL DE SEGURIDAD SOCIAL EN SALUD

Jorge E. Machado-Alba, Claudia Giraldo-Giraldo

Journal Title:Investigaciones ANDINA
Abstract


Objectives: to identify possible pharmacological interactions that could be related with probable negative results associated with medications, by means of searching active data bases of patients affiliated to a health system. Methods: by reviewing statistics of medicines known to present risk interactions throughout systematic data bases of medication providers, in about 4.5 million users in Colombia. Results: the findings reveal cases of simultaneous use of three phosphodiesterase-5 enzyme inhibitors, antagonism between levomepromazine and cabergoline; use of 2 proton pump inhibitors and sucralfate at the same time; irregular dispensation of antiretroviral agents, non-indicated use of somatropine and simultaneous use in the central nervous system of stimulating and depressive drugs. Conclusions: the active search allows optimizing resources, to prevent adverse events that can potentially cause morbidity, or to determine problems that could be responsible for the therapeutic failure, anticipating the appearance of probable risks to the patient.

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