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Paper Details

SEGUIMIENTO AL ESTADO SEROLGICO DE MUJERES EMBARAZADAS QUE RECIBIERON INADVERTIDAMENTE LA VACUNA ANTIRRUBELICA, BOGOT, COLOMBIA, 2005-2006

Lina Morn Duarte, Mara Teresa Espitia

Journal Title:Investigaciones ANDINA
Abstract


Antecedents: during 2005 and 2006 Colombia implemented a nationwide day of vaccinations against Measles and Rubella, in the event it was to be expected that some pregnant women would be inadvertently administered with the vaccine. In order to prevent any detrimental effects on the pregnancy, these women were subsequently monitored by means of an epidemiological study. Methods: a field study was conducted into women aged between 14 and 39 who had received the Rubella and Measles vaccine without knowing that they were pregnant. Immunoglobulin M (IgM) and immunoglobulin G (IgG) tests for the detection of the rubella virus were applied in each case. If, within a period of no greater than 30 days from the moment of vaccination, the IgM results proved negative and the IgG results positive then the women were declared immune. However if the IgM results taken immediately after the vaccination registered as positive then the women were categorised as susceptible to the virus. The woman were classified as indeterminate if they showed negative IgM results and positive IgG results in a period exceeding the 30 days lapse between the vaccination and the application of the serological tests. Results: among 3,489 pregnant women that were administered with the vaccine, 2,732 displayed IgM results of (-) (78.3%); 510 displayed positive indices in the IgG immunity tests, and 87 were negative-susceptible in this case-; out of all the cases treated in the IgM (+) band 277 (7.9%) were classed as susceptible. This is to say that 364 (10.4%) cases were identified as susceptible whilst 510 (14.6%) were deemed immune and only 66 (1.8%) appeared as doubtful or without result on second trial. 414 (11.8%) did not obtain their results in a laboratory. Those who proved HIV positive in reaction to the IgM - results are specific to the time lapse between the date of vaccination and the application of the serological tests were as follows: 5.4% 0-30 days); 10.1% (31-60 days); 8.4% (61-90 days), and 8.5% ((? 90 days). With regards to the age of the patients, of the total number or women considered susceptible, it was discovered that the group aged between 16 and 25 years which represents 46.9% (130/277) were more susceptible (6.6%) to rubella. Conclusions: the serological and epidemiological data collected warranted the cross sector application of the vaccine to women between the ages of 14 39 years. None of the pregnant women subsequently monitored displayed signs of congenital rubella syndrome that could have been the result of the preventative rubella vaccine.

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