Advances in Agricultural Technology & Plant SciencesISSN(p): | ISSN(e):2640-6586
FORMULATION AND EVALUATION OF MATRIX TABLETS OF ROPINIROLE HYDROCHLORIDE FOR ORAL CONTROLLED RELEASE
M. Mohan Varma, and M. Santosh Kumar
Journal Title:Indian Journal of Pharmacy and Pharmacology
The objective of the present investigation is to prepare and evaluate the controlled release matrix tablets of a water soluble drug (ropinirole hydrochloride) using direct compression and Wet granulation technology. Ropinirole Hydrochloride is a hydrophilic drug and has pH independent solubility. It is used in the treatment of idiopathic parkinsonsdisease. The controlled release matrix tablets of ropinirole hydrochloride were prepared using various polymers: guargum, sodium alginate and carbopol 940P.The matrix tablets were prepared using two strategies: direct compression and wet granulation. The tablets were evaluated for the various quality control parameters and the drug release was evaluated in pH 1.2 and in pH 7.4 buffer. The optimized formulation containing drug and guar gum controlled the drug release up to 8 hours. The drug release from the optimized formulation (drug: guar gum,1:2.5) followed first order kinetics and showed non-fickian diffusion mechanism. The FTIR studies indicated the lack of drug-polymer interaction. The formulated controlled release tablets can decrease the frequency of drug administration, decrease the plasma drug fluctuation and it can improve the patient compliance.