Journal of Applied Pharmaceutical ResearchISSN(p): | ISSN(e):2348-0335
HYPOTHESIS, PROGRESS AND PROBLEMS - CURRENT TREATMENTS FOR ALZHEIMER’S DISEASE: A REVIEW
Dinesh Raja, K.S.G. Arul Kumaran, C. Sankar, K. Selvaraj
Journal Title:Indian Journal of Pharmacy and Pharmacology
Alzheimer disease is one of the most complex and challenging neurodegenerative disorders. It has recently received considerable attention, especially in areas related to new treatments. Alzheimer disease is clinically characterized by progressive cognitive decline associated with impairment in activities of daily living and progressive behavioural disturbances throughout the disease course. The cholinergic system plays a vital role for learning and memory, and the memory impairment severity in Alzheimer disease is mainly associated with cholinergic dysfunction. Hence, restoration of cholinergic neurotransmission may help in treating patients with Alzheimer disease. Studies have revealed encouraging results with cholinesterase inhibitors to increase acetylcholine concentrations in the brains of patients with Alzheimer disease.