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Paper Details

ACTIVATION NETWORK CA2+-CELL ACTIVITY OF THE HIPPOCAMPUS IN THE LATE NEONATAL ONTOGENESIS

Yaroslava Igorevna Mitaeva; Artem Mikhailovich Mozherov; Rostislav Andreevich Sokolov; Irina Vasilevna Mukhina

Journal Title:Theoretical & Applied Science
Abstract


We investigate the spontaneous, ATP- and L-glutamate - induced changes in intracellular calcium in neurons and astrocytes CA3 field of rat hippocampus acute slices. This study allowed us to estimate the dependence of Ca2+ activity of cells of the CA3 field of rats hippocampus of late (R21-25) neonatal period of postnatal ontogenesis from the metabolic state of the cells associated with an increase in the release of neurotransmitters into the synaptic cleft. Furthermore, it was shown that in a mature network, where the spontaneous Ca2+ activity of the cells is low while maintaining excitation of the neural network, adding evoked excitatory neurotransmitters causing strict synchronization of cell activity

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