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Paper Details

The effects of inhaled Fluticasone on inflammatory markers in asthmatic patients

Hossein Hadinedoushan, Abolhassan Halvani, Elieh Abdollahi

Journal Title:Basic Research Journal of Medicine and Clinical Science

Inhaled corticosteroids are the most effective anti-inflammation drugs that are used in asthma treatment. This study investigated the effects of inhaled Fluticasone on C-reactive protein (CRP) serum levels and peripheral eosinophils in asthmatic patients. We studied 30 non-smoker adult asthmatic patients before and after using 500 g twice daily dose of inhaled Fluticasone for 4 weeks. Serum CRP levels were examined by enzyme-linked immunosorbent assay method. Also, peripheral eosinophil percentage was determined using automated cell counter. We used a paired t test to compare serum CRP values and peripheral eosinophils before and after the inhaled Fluticasone usage. Our results showed that serum CRP levels were significantly different before using inhaled Fluticasone (2.391.98g/ml) compared with 4-week treated inhaled Fluticasone (1.581.37 g/ml) (p=0.001). Moreover, there were significant differences between blood eosinophils before (6.34.6%) and after (3.42.1%) using inhaled Fluticasone (p=0.001). No significant correlations were found between serum CRP levels and percentage of blood eosinophils before and after inhaled Fluticasone treatment. Besides, there was no significant correlation between serum CRP levels and gender before and after using Fluticasone. Our findings indicate that inhaled Fluticasone with decrease serum CRP and number of eosinophils may improve local and systemic inflammation in asthmatic patients. Keywords: Asthma, CRP, Eosinophil, Fluticasone, Inflammation