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Paper Details

Food allergies in patients with down syndrome disorder in Khartoum- Sudan

Hussam Ibrahim, Safaa A. Medani, Maha I. GadAlla, Yasir Y. Abbas, Abdulla H.Shareef, and Ahmed K. Bolad

Journal Title:Basic Research Journal of Medicine and Clinical Science

Background: Down syndrome (DS) is the most frequent trisomy in humans, being universally present across racial, gender or socioeconomic lines, and affecting approximately 1 in 800 live births. Down syndrome usually causes varying degrees of intellectual, physical disability and associated medical issues. The association of Down syndrome and food allergies has been shown in several studies outside Sudan, the evidence from these studies suggested that, (DS) patients suffer from multiple food allergies. Objective: This study was undertaken to look for the association and frequency of food allergy among Sudanese patients with Down syndrome and to study the different types of food antigens among them. Material and method: This was a cross-sectional study done in three rehabilitation centers in Khartoum state from January to February 2011. A total of 100 individuals were recruited, of those thirty-six were (DS) patients who had symptoms of food allergy, thirty-six (DS) patients without symptoms of food allergy and twenty eight healthy individuals as a control group. Blood Immunoglobulin E (IgE) levels were semiquantitatively measured using immunoblotting technique. Results: All Down syndrome patients with symptoms of food allergy showed positive results for IgE antibodies specific for one or more type of food antigen (100%), thirty two (89%) Down syndrome patients without symptoms of food allergy were positive for specific food antigen in one or more types of antigen and only two (7.1%) individuals from the control group were positive for one antigen of food allergy. Conclusion: The association between Down syndrome and food allergies in our study population was very significant; it is therefore of utmost importance to evaluate all (DS) children for food allergies. Key words: Down syndrome, food allergy, immunoglobulin E, Sudanese patients, immunoblotting technique.