Nitric Oxides in Periodontics
Rupang Parekh, Monali Shah, Neeraj Deshpande, Sonam Mufti.
Journal Title:Advances in Human Biology
Background: Nitric oxide (NO) is a free radical, that is, an uncharged molecule with an unpaired electron. NO is a molecule, involved in vascular regulation, homeostasis, bone formation and resorption, neuro-transmission, and immune function. It also has antimicrobial activity and is considered to be an important molecule against infectious diseases, such as periodontitis. NO works as an effector of host-induced tissue damage mediated by the production of proinflammatory cytokines, prostaglandins and by the production of reactive nitrogen species. It might play a role in the pathogenesis of periodontitis and subsequent bone loss, either directly or indirectly by modulating the production of other pro-inflammatory cytokines. Although little has been published on its role in oral diseases, it certainly has important actions in periodontal diseases. Hence, this review will throw a light on the role of nitric oxide in periodontal disease based on recent evidences.