Azithromycin in Periodontics
Chirayu Shah, Monali Shah, Deepak Dave, Prasad Nadig, Amit Shah.
Journal Title:Advances in Human Biology
Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is used to treat many different infections, including acute otitis media, nonstreptococcal bacterial pharyngitis, gastrointestinal infections such as traveler's diarrhea, respiratory tract infections such as pneumonia, cellulitis, babesiosis, bartonella infection, chancroid cholera, donovanosis, leptospirosis, lyme disease, malaria, mycobacterium avium complex disease, neisseria meningitis, pelvic inflammatory disease, pertussis, scrub typhus, toxoplasmosis, and salmonellosis. It is used to prevent bacterial endocarditis and some sexually transmitted infections including those from unprotected sex or sexual assault. Azithromycin could have a triple role in the treatment and resolution of periodontal diseases: suppressing periodontopathogens, anti-inflammatory activity and healing through persistence at low levels in macrophages and fibroblasts in periodontal tissues, even after a single course of three tablets. If future periodontal research confirms these properties, it could become a valuable host-modulator in periodontal treatment.