Natriuresis does not account for urinary concentration inhability in the chronically undernourished rat.
Edinéia Goedert, Ana Durce Oliveira da Paixão, Carmen de Castro-Chaves.
Journal Title:Revista Agraria Academica / Agrarian Academic Journal
Through different concentrations of sodium in the diet, we investigated whether the natriuresis observed in the DBR rats since weaning resulted from the higher Na + intake or from its lower conservation by the kidney and its effect on the urinary concentration. For this purpose, we used a multicentre diet, locally called the regional basic diet (DBR) and 60 male Wistar rats, treated from weaning with: (i) control diet, by the American Institute of Nutrition (AIN); ii) DBR supplemented with low Na + content (0.06%), the DBR group; (iii) DBR supplemented with normal Na + content (0.3%), the DBRnorm group; iv) DBR supplemented with high Na + content (3.12%), the DBRhiper group. The excretion capacity in relation to sodium intake was similar between these two groups (99.01 ± 0.12 vs 99.02 ± 0.17%). Malnutrition compromised the urinary concentration mechanism.