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Paper Details

CASE REPORT: SYMMETRIC FLEXURAL EXANTHEMA TO DICLOFENAC     

Dr Paul Henry 

Journal Title:International Journal of Medical Studies
Abstract


Symmetric intertriginous and flexural exanthema (SDRIFE) is a rare  self limiting drug reaction characteristically affecting the intertriginous areas.  The common offending drugs are aminopencillins, beta lactam antibiotics and chemotherapeutic agents. Here we report a 68 year old male  who developed  well defined  symmetric  erosions involving bilateral axilla, upper and inner thighs and  genitalia with  dusky hue of  the surrounding skin and mucosal lesions after twelve hours  of  intake of  diclofenac  sodium. One year later on re exposure to the same drug, he developed an exactly similar clinical picture. Patient recovered with hyperpigmentation during both the episodes   on   withdrawal of the offending drug and administration of systemic steroids. To the best of our knowledge, this is the first report of  recurrent SDRIFE to diclofenac sodium with unusual features of erosive lesions ,mucosal involvement and the striking resemblance to fixed drug eruption.     Key words: Symmetric intertriginous and Flexural exanthema, Fixed drug eruption, Diclofenac sodium. 

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