Pulse Pressure Index as a Discriminator of Predicting the Cardiovascular Events in Hypertensive Patients Treated with Drugs Acting on Angiotensinogen-Angiotensin Pathway
Marwan S. Al-Nimer, Ismail I. Hussein ,and Yagub S. Saleh
Journal Title:Al-Anbar MedicalJournal
Background: Pulse pressure index as a function of pulse pressure divided by systolic blood
pressure served a useful predictor of cardiovascular events.
Objectives: Our aim was to assess the pulse pressure index as a discriminating variable of
predicting cardiovascular events in untreated hypertensive patients and treated with one member
of angiotensin converting enzyme inhibitors or angiotensin receptor blockers by using the scores of
Materials and methods: This observational cross-sectional study, including 140 patients who
grouped into; Group I (n = 30): untreated hypertensive patients; Group II (n = 60): patients
treated with angiotensin receptor blockers; and Group III (n = 50): patients treated with
angiotensin converting enzyme inhibitors. Anthropometric measurements, lipid profile, and blood
pressure were determined. The probability of ten-year of cardiovascular events was calculated
according to the Framingham study scores using The University of Edinburgh Cardiovascular Risk
Results: There is a non-significant difference between Groups and within Groups of age, smoking
habit, and the values of the cardio metabolic risk factors. Pulse pressure index as an independent
risk factor found to be a significant discriminator of 10-year prediction of cardiovascular events by
using the receiving operating characteristic curves.
Conclusion: The pulse pressure index is a useful discriminator of predicting cardiovascular events,
and it will improve the Framingham prediction risk among hypertensive patients.