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Paper Details

The Effect of Selenium on the Blood Radioimmunological Indexes Induced by High Dose of Fluorine

Jiayong Zou, Xinying Lin, Jianchao Bian, Qiuli Zhu, Xiaoyan Zou

Journal Title:Nature Environment and Pollution Technology

Endemic fluorosis is prevalent in China, which can seriously impair the bones, teeth and cardiovascular system. The study was intended to explore antagonism of selenium (Se) on high dose fluorine (F) inducing plasma 6-Keto-prostaglandin F1a,Thromboxane B2 and Endothelin-1. Twenty male rabbits were randomly divided into 4 groups: High F group (NaF,100mg/L), Se group (Na2SeO3,1mg/L), High F + Se group (NaF,100mg/L; Na2SeO3,1mg/L) and Control group (without fluorine and selenium). The ear vein blood was collected for measurement of serum selenium and fluorine at the end of 0, 3rd and 6th months. At the end of 6th months, plasma 6-Keto-prostaglandinF1a (6-K-P), Thromboxane B2 (TXB2) and Endothelin-1 (ET-1) were detected. Serum fluorine was increased in high F group and serum Se was increased in Se group. Plasma 6-K-P was decreased, while the plasma TXB2 and ET-1 increased with the development of fluorosis. Compared with the high F group, the plasma 6-K-P was higher (p