Psoriasis: Tumor Necrosis Factor –α, Interleukin 18, C Reactive Protein Polymorphism , and Osteopontin Role.
Ibrahim Mohamed Abed. Ph D Theses conducted in Tikrit University College of Medicine [TUCOM], Iraq in 2012.
Journal Title:Aalborg Academy Journal of Medical Sciences
Background: Psoriasis is a common chronic skin disorder with prevalence of 2.7% in Iraqi community. Many factors affect the prevalence of psoriasis which include genetic, environmental, infectious, immunological, biochemical, endocrinological and psychological. Psoriasis is a chronic inflammatory disease with unknown exact pathogenesis, which may be started as skin condition that subsequently associated with systemic complications. The recurrent proliferative inflammatory processes in subject with psoriasis may lead to abnormal lipid metabolism and associated with cardiovascular diseases. Gene polymorphisms represent either a protective or risk factors for development of psoriasis and cardiovascular disease. Aim of the Study: The aim of the present study is to provide a picture about the association between psoriasis and atherosclerosis.