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Paper Details

Adiponectin hormone and Measurements of Plasma Membrane Voltage in Isolated Adipocytes of Control and Diabetic Patients.

Mohammed F. Alkotobe1 , Nabaa Saad Ibadi2 . Alkitab University College, Department of Pharmacology, Alton- kobry, , Kirkuk, Iraq. 1 Physiology Department, Tikrit Univ .College of Medicine Tikrit, Iraq2 . Correspondence author: Mohammed F. Alkotobe, Alkitab University College - Department of Pharmacology. Alton-kobry, Kirkuk, Iraq.

Journal Title:Aalborg Academy Journal of Medical Sciences
Abstract


Background: Diabetes is one of the most important and social-economic problem worldwide and characterized by serious metabolic, vascular and neurologic complications. Aim: To isolate adipocytes in diabetic patients and estimate the electrical potential difference (membrane potential) of isolated adipocytes. Methods: Biopsy of lipid tissue of diabetic patients were taken In Bin-Sina hospital and then adipocytes were isolated in laboratory of College of Science, Baghdad University.. Results: The Adiponectin mean serum value was significantly (P<0.001) higher in diabetic patients (15.60 ± 1.73 g/ml) as compared to controls (5.80 ± 1.22 g/ml). While the measurement of isolated adipocytes current was significantly (P<0.001) different in diabetic patients (-30.4 ± 4 mV) from that in controls ( -61 ± 5mV). Conclusion: Adipocytes plasma membrane voltage was with significant difference in diabetic patients as compared to controls and this reflect the inflammatory changes at cellular level in diabetes. Key words: Diabetes, Adiponectin, Adipocytes, plasma membrane voltage.

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