REVIEW ARTICLE: Maternal Infections Associated with Bad Obstetric Outcome: Cytomegalovirus and Herpes Simplex Virus.
Mohamed Almoustafa Alsamarai, Laboratory Investigation Department, Samara University College of Applied Sciences (SUCOAS), Samara, Iraq.
Hala Majeed Hassan, Tikrit University College of Veterinary Medicine, Tikrit.
Correspondence author: Mohamed Almoustafa Alsamarai, Laboratory Investigation Department, Samara University College of Applied Sciences (SUCOAS), Samara, Iraq.
Journal Title:Aalborg Academy Journal of Medical Sciences
Introduction. Cytomegalovirus (CMV) infection is with global distribution and range of 30-100% [1, 2]. CMV infection is the most common congenital viral infection worldwide . The sign of congenital CMV infection encountered most frequently is hearing loss, which wills 12.6% of congenitally infected newborns and congenital CMV infection form 10-20% as a cause of total hearing loss in children . About 10% of the live-born infants with congenital CMV infection are symptomatic at birth. Where as an additional 10% of the infected newborns will develop permanent sequelae in the following years.  Among children with bilateral profound hearing loss, the hearing incapacity is attributable to congenital CMV infection in one out of five patients. This makes CMV the leading cause of non genetic congenital hearing impairment . Asymptomatic CMV infection at birth may develop hearing loss in adolescent age . In spite of the detailed knowledge about the epidemiology and pathogenesis of CMV infections in pregnant women, this infection stays largely unknown to the majority of women in the United States .Few, if any pregnant women are routinely screened for CMV infections during pregnancy. Questions surrounding the suitability of serologic screening for CMV during pregnancy are important because over 90% of primary maternal CMV infections during pregnancy are asymptomatic and may remain asymptomatic in the fetus. Israel and eight European countries (France, Belgium, Spain, Italy, Germany, Austria, Portugal, and the Netherlands) routinely screen the majority of pregnant women serologically for CMV This routine serologic screening occurs without the recommendations or guidelines of any governmental agency, authority, or a professional medical society .