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Paper Details

Preliminary Antimicrobial Screening of Compounds (Emblica Officinalis Gaertn., Terminalia chebula Retz., Piper longum Linn., Plumbago zeylanica Linn.)

Sapna Chaudhary, Kanhaiya Agrawal and Vinod Kumar Joshi

Journal Title:International Journal of Ayurveda and Pharmaceutical Chemistry

Evaluation of antimicrobial effect of hydroalcholic extract of polyherbal drug Amalakyadi gana of sushruta samhita in sutra sthana 38th chapter containing Amalaki, (Emblica officinalis Gaertn.), Haritaki (Terminalia chebula), Pippali (Piper longum Linn.,) and Citraka (Plumbago zeylanica Linn.) mentioned as Sarvajvarahara (to alleviate all kind of fever). It is Caksusya (Beneficial to eye), Dipana (enhances the agni), Vrsya (Aphrodisiac) and Kapharocakan (Eversion of food due to Kapha). The antimicrobial activity of newly synthesized compound was first screened by disc diffusion method against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC(American Type Culture Collection) 27893, Staphylococcus aureus ATCC 25323 (Gram-positive) and four fungal strains namely Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida tropicalis ATCC 750, Candida parapsilosis ATCC 22019 according to the guidelines of National Committee for Clinical Laboratory Standards (NCCLS, 1997). The Zone of inhibition (in mm) was formed maximum in Staphylococcus aureus (250.35) in comparison to Standard drugs (10μg/disc) - 24(Ampicilin). In other microorganism Pseudomonas aeruginosa, Candida albicans, Candida tropicalis, Escherichia coli, Candida krusei, C. parapsilosis and Plesiomonas shigelloides , the zone of inhibition was observed as follows; 16±0.57, 12±0.47, 12±0.39, 11±0.68, 11±0.67, 11±0.29 and 10±0.41, respectively