Synergistic Hypoglycemic Effect of Pumpkin Polysaccharides, Pueraria Flavonoids and Pu-erh Tea Theabrownin in Type 2 Diabetic Mice through Enhancing the Nrf2/HO-1 Signaling Pathway
Xue Chen1 , Zixuan Liu1 , Ping Xiao1,2, Haiqing Wu1 , Yeni Zhang1 * and Jinfu Liu1,2*
Journal Title:Journal of Clinical Nutrition and Food Science
In order to investigate the hypoglycemic effects and potential mechanism of Pumpkin Polysaccharides, Pueraria Flavonoids and Pu-erh Tea Theabrownin on diabetes, type 2 diabetes mellitus (T2DM) mice were established and treated with the active components of plants. Results showed that the active components of plants treatment could result in the decrease of blood glucose and possessed the efficacy of insulin resistance alleviation in the diabetic mice. Furthermore, the levels of Nrf2/HO-1were up-regulated by the active components of plants, which indicated the involvement of the Nrf2/HO-1 signal pathway in the hypoglycemic mechanism. Results suggested that Pumpkin Polysaccharides, Pueraria Flavonoids and Pu-erh Tea Theabrownin could ameliorate the T2DM and combined groups had much more efficient effects than its single groups which might be a promising candidate functional food or medicine for T2DM treatment.