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Paper Details

Laminaria japonica Polysaccharide Reduces Lipids and Leptin Levels in Hyperlipedemic Mice

Yunliang Guo

Journal Title:Basic Research Journal of Medicine and Clinical Science

The aim of this study is to examine the effects of Laminaria japonica polysaccharide (LJPS) on lipids and leptin metabolism in hyperlipidemic mice. The hyperlipemia models were established by feeding fat-rich forage to Kunming mice for four weeks and administered with different doses of LJPS (75mg/d, 150mg/d, 300mg/d). Triglyceride (TG) and total cholesterol (TC) in serum were determined with enzymic method and cholesterol oxidation method. The free fatty acid (FFA) and leptin in serum were determined by enzyme linked immunosorbent assay (ELISA). The results showed that the serum levels of TG, TC, FFA and leptin in the hyperlipidemic group were higher than those in control group (P