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Paper Details

Phosphatidylserine: A Well-Studied Cognitive Solution for Supplements and Functional Foods

Itay Shafat

Journal Title:Journal of Clinical Nutrition and Food Science

Phosphatidylserine is a structural component of cell membranes, which can be found in all biological membranes of plants, animals and other life forms. The human body contains about 30g of phosphatidylserine, close to half (~13 g) of which is found in the brain. Phosphatidylserine plays a vital role in several cellular processes, such as activation of cell-membrane bound enzymes, and is involved in neuronal signaling. Phosphatidylserine can also be found in human diet, though in the last decades it is estimated that average consumption levels have declined by approximately 50%. Phosphatidylserine has been extensively studied as a dietary supplement, mainly for cognitive health in various populations, from children with ADHD to elderly, healthy and diseased alike. Preclinical and clinical studies demonstrated that oral administration of phosphatidylserine is safe and well tolerated, and can improve cognitive functions, relieve daily stress, improve skin health, have benefits for those dealing with sports, and more. The physical traits of phosphatidylserine, such as the fact that it is an amphiphilic molecule or its lack of organoleptic problems, makes phosphatidylserine especially suitable for functional foods. Together with the growing consumer trend preferring functional foods over the traditional tablets and capsules, phosphatidylserine can be an interesting addition to foods for children, seniors, athletes and others.