Vitamin D3 Supplementation to Children; A Pilot-Study of Adherence
Journal Title:Journal of Clinical Nutrition and Food Science
Background: Non-adherence to supplementation is a widespread public health problem and according to the World Health Organization adherence among patients with chronic disease averages is only 50 percent. The difficulties in treating children with obesity are well-known and the outcome is highly dependent on adherence. Obesity is associated with a low vitamin D3 status and it is discussed if supplementation should be considered for obese children, when low vitamin D3 status increases the risk of several diseases. Objectives: The study aim was to determine the convergence between self-reported adherence and serum 25(OH)D3 levels, the circulating vitamin D3 metabolite. Thereafter to compare the adherence between children with obesity vs normal-weight children. Method: The study design was a prospective longitudinal study of 20 children (11-17 year of age) with a low vitamin D3 status. The children were recommended supplementation for 2 months. Adherence was checked during visits at the clinic in combination with bloodsampling (25(OH)D3 ). Results: All the participants had a high self-documented adherence (75%), which was in line with the vitamin D3 levels that increased significantly after 2 months. No difference was seen in the adherence between obese and normal-weight children. Conclusion: The convergence between self-reported adherence and serum 25(OH)D3 levels was high. The adherence to vitamin D3 supplement for children works well due to frequent contacts with a pediatric nurse in combination with blood sampling with no difference between obese or normal-weight children.