Screening of Antihyperlipidemic Activity of Flavonoid Obtained From Leaves of Andrographis Paniculata
Nagarathana P.K.M., Sahu Satya Narayan, Sridhar Bommineni and Sah Dipendra Kumar
Journal Title:International Journal of Ayurveda and Pharmaceutical Chemistry
AIM:The aim this study was to evaluate the anti-hyperlipidemic activity of leaves of Andrographis paniculata in rats. METHOD: Hypercholestermia was induced by giving coconut oil 25%, cholesterol 1%, and cholic acid 0.5%. Theatherogenic diet and the treatment were given simultaneously for 26 days. On the 27th day, blood was collected by retro orbital puncture for the analysis of serum triglycerides, cholesterol, HDL, VLDL and glucose. Rats were treated with flavonoid of Andrographis paniculata (100, 200 mg/kg;po;/day/26 days) and atorvastatin(10 mg/kg;ip;day/30days) which served as standarddrug. RESULT:Andrographis paniculata treated group showed significant decrease in LDLcholesterol, total cholesterol, triglycerides, AST, ALT, ALP and increase in HDL-cholesterol, Albuminandtotalprotein. CONCLUSION: From result, it was concluded that flavonoid of leaves of Andrographis paniculata shows antihyperlipidemic activity.