Anti-Cancer Activity of Steroid of Vitex Leucoxylon
Nagarathna P.K.M, Prabhat Pal, K. Meghana and Dipendra kumar Sah
Journal Title:International Journal of Ayurveda and Pharmaceutical Chemistry
Objective: The aim of this study was to investigate the anti-tumour effect of the methanolic extract of the leaves of Vitexleucoxylon Linn (Verbenaceae). Methods:The study sampled 30 mice, divided into 5 groups (6 in each). Ascites tumour was developed by administering Ehrlich ascites cells (0.1ml/10gm body wt of mouse,i.p) from 1x106 cells. The mice were treated with steroid of Vitexleucoxylon and 5-flurouracil which serves as standard. The several changes of anti-tumour potential of steroidal extract of Vitexleucoxylon were accessed. Results: Steroid of leaves of Vitexleucoxylon treated group showed significant decrease in total number of cells, percentage viability and tumour volume of Ehrlich Ascites Carcinoma in mice. Conclusions: From results, it was concluded that steroid of leaves of Vitex leucoxylon showed anti-tumour activity.