An Experimental Study on the Anti inflammatory Effect of Roots with that of Leaves of Nirgundi (Vitex negundo Linn, Family Verbenacea)
Mridula MK and Jollykutty Eapen
Journal Title:International Journal of Ayurveda and Pharmaceutical Chemistry
Nirgundi (Vitex negundo Linn, Family Verbenaceae) is a widely used medicinal plant, and therefore a fastly depleting one due to indiscriminate collections by the local herbalists and habitat destruction. Almost all its parts are used medicinally, especially roots and leaves. Anti inflammatory effect of this plant is clearly mentioned in ayurvedic books (nighantus) and its root and leaf extracts are proven effective experimentally. There is an increased demand for herbal drugs, due to the side effects of the currently available anti inflammatory drugs. For this reason, as well as to encourage the use of alternate plant parts, the current study was conducted. Aim of the study was to compare the anti inflammatory effect of kwatha (decoction) of roots and leaves of Nirgundi in acute inflammation by carrageenan induced hind paw oedema in albino rats. Comparison of change in paw volume of the test groups with control at 1hr, 3hrs and 5hrs after inducing inflammation by injecting Carrageenan, is used as the assessment criteria. From the results it can be concluded that leaves of Nirgundi showed a better anti inflammatory effect than its roots in carrageenan induced acute inflammation. Also both roots and leaves showed mild anti inflammatory effect in acute stage of Inflammation.