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Effect of Endosulfan Toxicity on 1st Stage of Spermiogenesis Leading to Infertility

Asiya Nisa, Yashowardhan Suman, Mehjabeen1 and Suhail Jeelani Shah

Journal Title:Acta Scientific Women's Health
Abstract


Toxicities of organochlorine pesticides like Endosulfan show adverse effects on many organs and organ systems like liver, kid-ney, testes, muscles, immune system and hematological system. Most of the previous studies focused on effects of organochlorine on activity of spermatogenic cells. However, there is very little research reporting effects of endosulfan on spermiogenesis till date. Therefore, the current study was aimed to assess the effect of Endosulfan on spermiogenesis in the testes of mice model. A 5 mg/gm body wt. Endosulfan was administered to mice by oral gavage method. Normally in the beginning of spermiogenesis, the sperm head gets embedded in the sertoli cell and finally released from the seminiferous tubules. It is very significant to note that the testes in endosulfan treated mice. They were found to get affected at an early stage (from spermatids to 1st stage of spermiogenesis), as com-pared to any other organochlorine pesticide. The present study also confirms that only oral administration (5 mg/gm body wt.) for 20 days shows effect on spermiogenesis in 30% of mice. Furthermore, in 20 days treated mice, notable changes were seen during the 1st stage of spermiogenesis. Significant decrease in testosterone level (P ≤ 0.0001) and sperm count (P ≤ 0.001) was observed after endosulfan exposure. Abnormal spermatozoa in the lumen of seminiferous tubules were found to be very few in number and with a non-motile tail. Approximately 30% of the heads of spermatozoa were found with rounded acrosome, which will lead to infertility.

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