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Currently Used Drugs for Prevention and Treatment of Acute Organ Rejection

Vera Maravić-Stojković and Branislav Stojković

Journal Title:Acta Scientific Women's Health
Abstract


It is clear from the knowledge gained from the ancient times that healing is not as simple process as it seems. During long periods of time, major advancements in technology, pharmacology, and medicine have enabled the extraction of countless remedial prod-ucts from the plants. And not only from plants. Natural products have also been extracted from animal organs and later, synthetic equivalents with identical properties have been developed. The fascinating progress of humankind was achieved when the animal organs have become available as a drug. Nevertheless, revolutionary progress in solid organ transplantation was marked by the in-troduction of the cyclosporine A. Transplant immunology has become a leading science in modern medicine. Since then, solid organ transplantation has become a routine procedure accomplished with the help of protocols of immunosuppressive therapy. This article is designed as an overview of currently used immunosuppression in solid organ transplantation. Currently available groups: steroids, antimetabolites, polyclonal and monoclonal antibodies, calcineurin inhibitors, proliferation signal inhibitors, are described closely below. Each transplant center creates their own protocols. Protocols for immunosuppressive therapy offer three major strategies: in-duction, maintenance and therapy for treating acute rejection. The backbone of immunosuppression in organ transplantation recipi-ent: cyclosporine A and tacrolimus, have been widely used as maintenance therapy combined with adjunctive immunosuppressant. These drugs are in use either as a prophylaxis or as the part of the maintenance immunosuppressive treatment. Induction therapy provides immunologic ablation with upstream antibody therapy as prelude to induce graft tolerance. Protocols are briefly described in the text

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