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Effects of systemic inflammatory response on coronary artery bypass grafting

Nihan Yeşilkaya1, Orhan Gökalp1, Hasan İner1, Yüksel Beşir1, Hüseyin Durmaz2, Yaşar Gökkurt2, İhsan Peker2, Levent Yılık1, Ali Gürbüz1 1Department of Cardiovascular Surgery, Izmir Katip Çelebi University Faculty of Medicine, Izmir, Turkey 2Department of Cardiovascular Surgery, Izmir Katip Çelebi University Atatürk Research and Training Hospital, Izmir, Turkey  

Journal Title:Cardiovascular Surgery and Interventions

Objectives: In this study, we aimed to investigate the effects of systemic inflammatory response syndrome (SIRS) on postoperative results of coronary artery bypass grafting (CABG). Patients and methods: Between April 2016 and April 2018, a total of 287 patients (203 males, 84 females; mean age 62.5 years; range, 21 to 89 years) who underwent CABG were retrospectively analyzed. Data were collected from the medical records. The diagnosis of SIRS was made according to the criteria used by Boehme. Results: In total, 83.9% of the patients had postoperative SIRS. Univariate analysis revealed that the predictive factors of SIRS were age, preoperative EuroSCORE, on-pump surgery, and preoperative low hemoglobin levels. However, age was detected as the only predictive factor in the multivariate analysis. The diagnosis of SIRS did not affect hospital mortality, neurological complications or length of hospital stay, whereas it prolonged the weaning period and length of intensive care unit stay. Conclusion: Our study results show that SIRS has no significant effect on mortality and neurological complications in CABG patients. On the other hand, special attention should be given to the inflammatory response, as it prolongs the weaning period and length of intensive care unit stay