RNAi-Mediated Antiviral Approach to SARS-CoV-2
P Shaik Syed Ali, A Sheeza and J Jasmine.
Journal Title:Acta Scientific Microbiology
In 2003, severe acute respiratory syndrome (SARS) caused by SARS coronavirus (CoV) affected 26 countries with 8000 cases. The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first reported in Wuhan, China in December 2019. It rapidly evolved into a pandemic disease resulting in an unprecedented health crisis. Antiviral drugs and vaccines against SARS-CoV-2 and related coronaviruses are crucial to prevent any future epidemics and pandemics. RNA interference (RNAi), an RNA guided post transcriptional gene silencing mechanism, plays important role in viral defense in mammals including humans. RNAi can inhibit the virus replication and expression of viral proteins through the leverage of small interfering RNAs (siRNAs). Therefore, RNAi an innate viral defense mechanism distributed in human cells might be a potential antiviral approach to SARS-CoV-2