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Feto-Maternal Outcome of HIV Positive Pregnant Women on HAART at the Gambia - Case - Control Study

Matthew Anyanwu1,2*, Samuel Anya2, Richard Offiong3 and Bissallah Ekele3

Journal Title:Acta Scientific Women's Health
Abstract


Human Immunodeficiency virus (HIV) infection in pregnant women remains a huge public health concern globally. There were conflicting reports regarding pregnancy outcome among HIV positive mothers. The aim was to compare pregnancy outcome among HIV-infected and uninfected women at Edward Francis Small Teaching Hospital, Banjul the Gambia. Pregnant women attending antenatal clinic at the hospital were prospectively recruited and followed up. HIV positive and negative mothers were matched for age and parity. Recruitment occurred irrespective of gestation age. At the time of delivery, obstetric and neonatal characteristics were entered into computer database. Mothers and their children were followed until 6 weeks postpartum. The data was analyzed with Epi-info version 7.1.5. Chi square at significant level of 0.05 and confidence level of 95% was used to determine significance. A total of 166 mothers, 55 HIV positive and 111 HIV negative controls were in the study. The age range was between 18 to 45 years and parity was 0 to 8. The measured adverse outcome includes; Low Birth Weight; 20% Vs 5.2% odds ratio (OR) 4.6; 95% confidence interval (CI) 1.46-14.2; P- 0.01220 and maternal anaemia (40% Vs 11% OR 5.4 95% CI 2.3 - 12.6; P-0.0001). Both showed statistical significant difference. Preterm delivery; 29.2% and 26.6%; OR 1.14; 95% CI 0.52 - 2.46; P-0.9 and stillbirth, low Apgar score at 5 minutes and NICU admission of 5.45%vs 0-0.9% showed no statistical difference; (OR = 6.3; CI; 0.6 - 6.25; P -0.21). HIV infection was associated with low birth weight and maternal anaemia.

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