Anti-Tubercular Agents: Overview
Kundan Tiwari*, Kiran Suryavanshi, Dhananjay Patil
Journal Title:International Journal of PharmaO2 (IJPO)
During the last few years, the pharmacy profession has expand significantly in terms of professional
services delivery and now has been recognized as an important profession in the multidisciplinary
provision of health care. The main objectives of tuberculosis therapy are to cure the patients and to
minimize the possibility of transmission of the bacillus to healthy subjects. Adverse effects of
antituberculosis drugs or drug interactions (among antituberculosis drugs or between antituberculosis
drugs and other drugs) can make it necessary to modify or discontinue treatment. We describe the
general mechanism of action, absorption, metabolization, and excretion of the drugs used to treat
multidrug resistant tuberculosis (aminoglycosides, fluoroquinolones, cycloserine/terizidone,
ethionamide, capreomycin, and para-aminosalicylic acid). We describe adverse drug reactions and
interactions (with other drugs, food, and antacids), as well as the most appropriate approach to special
situations, such as pregnancy, breastfeeding, liver failure, and kidney failure.
Keywords: Bactericidal, Bacteriostatic, Neuritis, Tuberculosis.