Pharmacological Investigation of Amaranthus paniculatus Seeds Extract
Bharti K. Parmar*, Dr. Navin Sheth
Journal Title:International Journal of PharmaO2 (IJPO)
Abstract- The focus while study is on development of Amaranthus paniculatus seeds as a Herbal sports medicines. As Amaranthus paniculatus seeds have high energy value hence hypothesized here, ‘it can be use as Herbal Sports Medicine’. The Wistar Albino Rats were used during study and accordingly experimental models were designed. A. paniculatus seeds water extract prepared then two groups of animals were set for the study; Test-1 (T1), Test-2 (T2) and respectively 250mg/kg, 500mg/kg of extract were administered orally. Change in the weight, swimming capacity, change in plasma creatinine, TG, glucose and certain electrolyte level were observed on animals. The results show that’s, there were not significant changes in weight gain (3.667±2.894g) for 500mg/kg of extract. There are significant differences in the swimming time to exhaustion between control group (101.3± 3.403 sec) and each treatment group (177.2±9.547sec and 213.2±5.896sec respectively for T1 and T2). In order to clarify its mechanism plasma biochemical parameters were measured in the forced swimming treated Rats. In present study 500mg/kg of extract shows significantly difference in treatment group when compared to control group for TG (70.83±7.769mg/dL), calcium (5.976 ± 0.1371mg/dL) and chloride (104.1±2.693mg/dL). And in plasma Creatinine, Glucose and Electrolytes like magnesium, phosphorus, potassium, sodium doesn’t having any significant differences. As seeds rich in Amino Acids- ornithine, arginine, alanine, glutamic acid, tyrosine, n-butyric acid, methionine, leucine and isoleucine that might be responsible for change in studied pharmacological activities. Key Words: A. paniculatus, Swimming capacity, Biochemical’s, Electrolytes, Amino Acids.