Weight Evaluation and Serum Indices Effect of Potash Administration on the Uterus of Pregnant Wistar Rat
Vidona WB1 * and Aduema W2
Journal Title:Medical & Clinical Research
Potash known as potassium carbonate (K2 CO3 ) is a mixture of salt with other components including impurities which coexist in mineral and salt is highly consumed in various forms by pregnant women. The aim of this research is to evaluate the weight and serum indices of potash on the uterus of pregnant wistar rat with the specific objectives of determining the effect of potash on the progesterone and estrogen level and weight index of pregnant wistar rat. A total of Twenty-five albino Wistar rat with weights ranging from (180-300g) were used and allocated into five groups of five animals each (4 females and a male) designated as groups 1, 2, 3, 4, and 5. The experimental groups 2, 3, 4, and 5 were administered different doses of potash. The animals were allowed for a period of one week for acclimatization under normal temperature (270C -300C) which they were being feed with normal feed (grower’s mash) and water ad libitum for one (1) week. Administration of potash were through the oral route. Group 1 served as the control group and was administered distilled water only. Group 2 received 300mg/kg of potash plus feed and water was given ad libitum for 7 days after detection of pregnancy. Group 3 received 600mg/kg of potash plus feed and water was given ad libitum. Group 4 received 900mg/kg of potash plus feed and water was given ad libitum. Group 5 received 1200mg/kg of potash plus feed and water was given ad libitum. After analysis from histological procedures, the progesterone and estrogen level of pregnant wistar rat were evaluated and observed that treatment with potash induced changes. However, the level of progesterone activities increased in the test groups (2, 3, and 5) when compared to the control group. As for estrogen level, the increased level was observed to be progressive in the test groups, with the highest seen with the 1200mg/kg group as well as the physical activity of the wistar rats. At the end of the study, the results showed that Potash alters progesterone and estrogen level as well as the physical activity of the wistar rats.