The Role of Cardiomyocyte Apoptosis in the Pathogenesis of Neuroleptic Cardiomyopathy
Volkov V P
Journal Title:Medical & Clinical Research
In the presented mini-review of the literature the role of cardiomyocyte apoptosis in the pathogenesis of neuroleptic cardiomyopathy is considered. Despite the insufficient development of the issue and the scarcity of literature data, various ways of negative influence on the heart of the side effect of cardiotoxic antipsychotic drugs leading to a decrease in myocardial mass due to the death of cardiomyocytes by apoptosis are convincingly shown, which initiates the process of heart remodeling with the subsequent development of myocardial dysfunction and progression of heart failure.