Synthesis, Characterization and Antimicrobial activity of bis(?-aminobutyrohydroxamate)oxovanadium(IV)
Journal Title:Asian Journal of Advanced Basic Sciences
ABSTRACT: The complex [VO(?-C3H8NCONHO)2] (I) has been synthesized by the reaction of VOSO4.5H2O with bimolar amounts of potassium-?-aminobutyrohydroxamate (K?-ABH) in methanol and characterized by elemental analyses, molar conductance and IR and ESR spectral. The molecular modeling dynamics of the complex suggest a square pyramidal geometry around vanadium. The antimicrobial activities of the newly synthesized complex and respective potassium hydroxamate ligand have been screened in vitro against six bacterial strains viz. Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae Salmonella typhi. and S. paratyphi and three fungal strains viz. A. niger, B. fulva and M. circinelloides has been assayed by MIC method. The complex has improved antimicrobial activity compared to free ligand. Keywords: Potassium-?-aminobutyrohydroxamate; bis(?-aminobutyrohydroxamate) oxovanadium(IV); spectroscopic studies; antimicrobial activity.