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Paper Details

STUDY ON RADICAL SCAVENGING AND GASTROPROTECTIVE EFFECTS OF ETHANOLIC STEM-BARK EXTRACT OF CARPOLOBIA LUTEA IN RODENTS.

Lucky Legbosi Nwidu,Jonah Sydney Aprioku,Fred Horsfal Guluye,

Journal Title:World Journal of Pharmaceutical Research
Abstract


This is a study of the antioxidant activity and gastroprotective effects of Carpolobia lutea ethanolic stem-bark extract (CL ESE) used as antiulcer in ethnomedicine. Experimentally induced gastric ulceration was achieved using acute models such as indomethacin, ethanol and serotonin. Amino acid analysis was by cation-exchange chromatography using automated amino acid analyser. Antioxidant potential was obtained by spectrophotometric assay using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH). The finger print of CL ESE was revealed by Jasco (Tokyo, Japan) HPLC and active compounds by phytochemical screening using standard procedure. The calculated LD50 is 866.025 mg/kg (i.p) using Lock's Method. In the indomethacin model, 43.3, 86.6 and 173.2 mg/kg CL ESE revealed ulcer inhibition rates of 51 %, 65 % and 76 %, respectively (p > 0.05, p < 0.05, p< 0.01) when compared with the control, while the pure drug, cimetidine (100 mg/kg) produced ulcer inhibition rate of 74 % (p < 0.01). In the ethanol model, 43.3, 86.6 and 173.2 mg/kg CL ESE produced ulcer inhibition of 20 %, 28 % and 40 % respectively; while cimetidine produced 36 % ulcer inhibition (p > 0.05). But combination of 86.6 mg/kg CL ESE and cimetidine (100 mg/kg) resulted in 44 % ulcer inhibition (p

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