• We are available for your help 24/7
  • Email: info@isindexing.com, submission@isindexing.com


Paper Details

A STUDY TO COMPARE THE HEPATOPROTECTIVE ROLE OF NIGELLA SATIVA AQUEOUS SOLUTION AND OIL SUSPENSION FOLLOWING ACETAMINOPHEN INDUCED HEPATOTOXICITY IN LAYER CHICKS

Ruqaiya Hasan*, Taseer A. Khan, Muhammad N. Khan, and Aiman Kanwa

Journal Title:World Journal of Pharmaceutical Research
Abstract


This investigation is performed to compare the reported hepatoprotective activity of Nigella sativa (Black Seed) aqueous solution and oil suspension by measuring the mean serum Aspartate transaminase (AST) and Alanine transaminase (ALT) levels f ollowing the administration of single toxic dose of 300 mg acetaminophen / kg body weight in Layer chicks. Blood samples drawn after 72 hours of drug administration showed a non significant rise of AST and ALT in the chickens treated with Nigella sativa aqueous solution and unaltered levels of serum AST and non significant high levels of ALT in the chickens treated with Nigella sativa oil suspension for 15 days, in comparison to controls. Thus it is concluded that Nigella sativa oil effectively provides hepatoprotection against toxic agents due to its active ingredient thymoquinone with antioxidant property, and there is a need to explore the minimum effective dose of Nigella sativa oil.

Download